ASCB Rainbow

Subgroup W

Subgroup W: Neurite Formation: From Neurite Initiation to Outgrowth

8:30-11:05 am, Room 119A
Organizer: Kazuhito Toyooka, Drexel University College of Medicine

The formation of the human brain requires the well-regulated saltation of more than 100 billion neuronal cells, necessitating their specific connections. To accomplish this, neurite initiation is followed by the outgrowth of neurites to eventually develop into dendrites and an axon. Disruption of these processes results in aberrant connections and causes a wide range of developmental defects including mental abnormalities. Thus, there is no doubt that neurite initiation followed by neurite outgrowth is essential, and that actin and microtubules are important for these processes. In the subgroup we will update recent findings and discuss the future directions of neurite formation, in particular focusing on the molecular mechanisms of neurite initiation and outgrowth and the functions of key players in this process.


 8:30-8:35 am- Introduction. Kazuhito Toyooka, Drexel University College of Medicine
8:35-9:00 am- Dawn of neurite formation: 14-3-3epsilon in neurite initiation. Kazuhito Toyooka, Drexel University College of Medicine
9:00-9:25 am- The when, where and maybe why of apical dendrite initiation in the cortex. Eric Olson, SUNY Upstate Medical University
9:25-9:50 am- MAP1B plays a key role in integrating signals that lead to cytoskeleton remodeling and determine axonal fate. Fatiha Nothias, Institut De Biologie Paris Seine
9:50-10:15 am- CLASPing neurites at the tip. Angela Ho, Boston University
10:15-10:40 am- Breaking the symmetry: signaling integration in neurite outgrowth. Ding Mei, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
10:40-11:05 am- Influence of subcellular localization of Rho GTPases on neurite otgrowth. Dianna Hynds, Texas Woman’s University

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