ASCB Rainbow

Subgroup U

Subgroup U: Translating Cell Biology Research into Effective Immunotherapies for Cancer

1:30 – 5:30 pm, Room 117
Organizers: Daniel J. Powell, Jr., University of Pennsylvania; and Keith L. Knutson, Mayo Clinic Jacksonville

This subgroup, presented in collaboration with the Society for Immunotherapy of Cancer, will address how the integration and translation of cell biology is necessary for effective cancer immunotherapy applications. The speakers will provide an overview of the critical cellular mediators and processes in cancer cell biology as it relates to success of immunotherapy, highlighting recent advances in immune escape/resistance, mutational landscape/neoantigen discovery, and current immunotherapeutic applications.


Theme 1: Tumor Plasticity and Mechanisms of Immune Resistance
1:30-1:55 pm- Mechanisms of Resistance to Cytotoxic Cell Killing. Steven M. Frisch, West Virginia University
1:55-2:25 pm- Cytokines and Tumor Immune Resistance. Claudia Palena, National Cancer Institute

Theme 2: Modifying Malignant Cells to Enhance Susceptibility to Immunotherapy
2:25-2:55 pm- Radiation Therapy and the Immune Response. Andy J. Minn, University of Pennsylvania
2:55-3:20 pm- Epigenetic Potentiation of Immunotherapies. Kunle Odunsi, Roswell Park Cancer Institute
3:20-3:35 pm- Break

Theme 3: Neoantigen Discovery and Applications
3:35-4:00 pm- Bioinformatic Pipelines. Yan Asmann, Mayo Clinic Jacksonville
4:00-4:30 pm- Mutation Load, Outcomes in Cancer and Personalized Cancer Vaccines. Aaron Miller, UC San Diego Health

Theme 4: Clinical Translation and Current Use of Immunotherapies
4:30-5:00 pm- Immune Checkpoint Blockade. Keith L. Knutson, Mayo Clinic Jacksonville
5:00-5:30 pm- Adoptive T Cell Therapy. Bruce Levine, University of Pennsylvania

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