ASCB Rainbow

Subgroup R

Subgroup R: From Motors to Cancer: Integrating Mechanical Forces across Scales

1:30 – 5:30 pm, Room 118A
Organizers: Johanna Ivaska, University of Turku; and Xavier Trepat, Institute for Bioengineering of Catalonia

Understanding complex system-level diseases, like metastatic cancer, requires sophisticated understanding of the biological processes involved. Many such processes, including motility, invasion, adhesion, matrix remodeling, and intra/extravasation, require cells to exert and sense physical forces. These forces are generated at the level of individual motor molecules and integrated across scales up to cell clusters and entire tumors. The aim of this subgroup is to bring together scientists working on different levels of this complex process to understand how mechanical forces impact cancer progression. The session will span the entire scope from modeling and detailed understanding of individual molecular motors, to force generation and dissipation in cellular cytoskeletal networks and adhesions, to collective cancer cell behavior in reductionist systems and in vivo.


1:30-1:35 pm- Introduction. Johanna Ivaska, University of Turku
1:35-2:05 pm- Simulating cell migration. David Odde, University of Minnesota
2:05-2:35 pm- Alterations in focal adhesion architecture and force transduction accompanying epithelial to mesenchymal transition. Alexander Dunn, Stanford University
2:35-3:00 pm- Integrin activity and cell adhesion dynamics. Johanna Ivaska, University of Turku
3:00-3:30 pm- Biomaterials approaches to assess the role of ECM dynamics in cancer. Claudia Fischbach, Cornell University
3:30-4:00 pm- Mechanics of collective cell invasion, division and folding, Xavier Trepat, Institute for Bioengineering of Catalonia
4:00-4:30 pm- What cell-level processes govern tissue solidification and surface tension during development and disease? Lisa Manning. Syracuse University
4:30-5:00 pm- Crosstalk between carcinoma-associated fibroblasts and cancer cells during invasion. Danijela Vignevic, Institute Curie
5:00-5:30 pm- Blood flow forces metastatic extravasation. Jacky Goetz, University of Strasbourg

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