ASCB Rainbow

Subgroup O

Subgroup O: Cell Cycle Regulation of Morphogenetic Behavior 

1:30 – 5:30 pm, Room 113B
Organizers: David Q. Matus, Stony Brook University; and Benjamin L. Martin, Stony Brook University

Eukaryotic cells undergo drastic rearrangements in response to their local microenvironment. These morphogenetic changes are required for many cell biological activities, including the cell shape changes associated with cell motility and migration. Dynamic changes occur in cytoskeletal architecture between interphase and mitosis, and animal cells exhibit additional morphogenetic phenomena as they differentiate and exit the cell cycle. Traditionally, simultaneous examination of cell cycle state and cell behavior has been challenging, due to a lack of live cell cycle biosensors. For this reason, it has been difficult to unravel the relationship between cell cycle state and execution of morphogenetic behavior. However, recent advances in both imaging and cell cycle state biosensors have facilitated re-examination of cell cycle regulation during morphogenesis, the central theme of this subgroup.


1:30-1:35 pm- Introduction.  David Q. Matus & Benjamin L. Martin, Stony Brook University
1:35-1:50 pm- Single-cell analysis of the proliferation-quiescence decision. *Mingwei Min & Sabrina Spencer, University of Colorado Boulder
1:50-2:05 pm- The proliferation-quiescence decision in development, cancer and aging. Laura Buttitta, University of Michigan
2:05-2:20 pm- Synchronization of the cell cycle in early Drosophila embryos. Stefano di Talia, Duke University School of Medicine
2:20-2:35 pm- Live-imaging embryogenesis in the annelid Platynereis with a live-cell cycle reporter reveals distinct cell cycling patterns arising from a single lineage. *B. Duygu Özpolat3, Mette Handberg-Thorsager2, Michel Vervoort1, and Guillaume Balavoine1, 1Institut Jacques Monod, 2Max Planck Institute of Molecular Cell Biology and Genetics, 3Marine Biological Laboratory
2:35-2:50 pm- Divergence of cell cycle regulation in space and time: a case study from spiralian micromeres. Deirdre Lyons, Scripps Institute of Oceanography, University of California, San Diego
2:50-3:05 pm- Mitosis choreographs FGF receptor redistribution during asymmetric heart progenitor induction in Ciona. *Christina D. Cota1, Matthew S. Dreier1, William N. Colgan1, Anna Cha2 and Brad Davidson1, 1Swarthmore College, 2Harvard Medical School
3:05-3:20 pm-  Single cell labeling and Fucci analysis in zebrafish reveal the importance of a regulated cell cycle during vertebrate body formation. Cortney M. Bouldin, Appalachian State University
3:20-3:35 pm- Cell cycle control of convergence and extension. Benjamin L. Martin, Stony Brook University
3:35-4:00 pm- Break
4:00-4:15 pm- Physical constraint induces cell division during neurulation. *Lance A. Davidson and Deepthi S. Vijayraghavan, University of Pittsburg
4:15-4:30 pm- Patterning the microtubule cytoskeleton during division and differentiation. Jessica Feldman, Stanford University
4:30-4:45 pm- Control of cell-cycle kinetics by EGF and Notch/Delta signaling during C. elegans vulval development. *Wolfgang Keil, Sha Shaham, and Eric D. Siggia, The Rockefeller University
4:45-5:00 pm- Cell cycle regulation of invasive behavior: insights from C. elegans anchor cell invasion. Abraham Q. Kohrman, Jayson Smith, Wan Zhang, and *David Q. Matus, Stony Brook University
5:00-5:15 pm- Mitotic cooperativity in collective cancer cell invasion. *Emily Summerbell and Adam Marcus, Winship Cancer Institute, Emory University School of Medicine
5:15-5:30 pm- Invasion, migration, and proliferation in development and metastasis. Andrew Ewald, Johns Hopkins University School of Medicine

* denotes presenting author

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