ASCB Rainbow

Subgroup L

Subgroup L: Actin Functions across the Tree of Life

1:30 – 5:30 pm, Room 118C
Organizers: Ronen Zaidel Bar, Tel-Aviv University; Buzz Baum, University College London; and Sally Horne-Badovinac, University of Chicago

Actin structure is highly conserved throughout the tree of life; however, over the course of evolution it has taken up diverse functions. In this subgroup, we will explore the function of the actin cytoskeleton in a range of organisms (including bacteria, plants, fungi, amoeba, protozoa, invertebrates, fish, amphibians, and mammals) in a variety of cellular processes, such as control of cell shape, division, fusion, polarity, motility, tissue morphogenesis, and transcription. Highlighting both common principles and unique specializations in actin function across species, the session will provide a broad evolutionary perspective through the lens of a single protein.


1:30-1:50 pm- How bacterial actin like filaments orient along the highest curvature to create and maintain rod shape. Ethan Garner, Harvard
1:50-2:10 pm- Actin dynamics during polarized growth in plants. Magdalena Bezanilla, Dartmouth
2:10-2:30 pm- Giardia’s Ventrolateral Flange: A static actin-based membrane sheet at the host-parasite interface. Alex Paredez, University of Washington
2:30-2:50 pm- CYRIPS – a Rac-binding protein that regulates dynamics of pseudopods – from Dictyostelium to cancer cells. Laura Machesky, Cancer Research UK Beatson Institute
2:50-3:10 pm- Ras activity stabilizes the actin fusion focus at cell contact sites prior to yeast cell-cell fusion. Laura Merlini (Martin lab), University of Lausanne
3:10-3:25 pm- Break
3:25-3:45 pm- Functional dissection of the Arp2/3 complex and the branched actin filament network during C. elegans cytokinesis. Fung Yi Chan (Carvalho lab), i3S – Porto University
3:45-4:05 pm- Polarization of actomyosin refines tissue material properties to buffer mechanical stress in Drosophila. Yanlan Mao, University College London
4:05-4:25 pm- Nuclear envelope breakdown by polymerized actin in starfish meiosis. Natalia Wesolowska (Lenart lab), European Molecular Biology Laboratory
4:25-4:45 pm- Actin regulation and dynamics in the morphogenesis of epithelial microridges in the zebrafish skin. Alvaro Sagasti, University of California, Los Angeles
4:45-5:05 pm- Anillin regulates Xenopus epithelial cell mechanics by structuring the medial-apical actin network. Torey Arnold (Miller Lab), University of Michigan, Ann Arbor
5:05-5:25 pm- Nuclear actin polymerization in mouse embryonic development. Kei Miyamoto, Kindai University
5:25-5:30 pm- Concluding remarks

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