ASCB Rainbow

Subgroup G

Subgroup G: Spatial and Temporal Control of Cell Signaling

8:30 am – 12:30 pm, Room 113A
Organizers: Ivan Yudushkin, Medical University of Vienna; and Brendan D. Manning, T.H. Chan School of Public Health, Harvard

Supported by PicoQuant

Coordinated assembly, localization and regulation of enzymatic complexes shape cellular signaling responses to the environmental cues. To ensure the fidelity of these reactions, the cells need to precisely position the enzymes and their substrates at specific compartments and provide mechanisms to trigger and quench the enzymatic reactions in time. The details of the biochemical architecture and coupling between subcellular localization and regulation of signaling enzymes are not well understood.

The speakers of this Special Interest subgroup will present new methods for fast, high-resolution mapping, quantitation and modeling of cellular biochemical activities and discuss how dynamic architecture of enzymatic activities defines the adaptive character and fidelity of cellular responses.


8:30-8:35 am- Introduction. Brendan D. Manning, T.H. Chan School of Public Health, Harvard
8:35-9:00 am- Spatio-temporal control of Rho GTPase Signaling by RhoGEFs and RhoGAPs. Oliver Rocks, Max Delbruck Center, Berlin
9:00-9:25 am- Functional selectivity of GPCR-directed drug action through location bias. Roshanak Irannejad, University of California, San Francisco
9:25-9:50 am- Illuminating the Cell’s Biochemical Activity Architecture. Jin Zhang, University of California, San Diego
9:50-10:15 am- Excitable networks in directed cell migration. Peter Devreotes, John Hopkins University
10:15 am- Break
10:45-11:10 am- Restricting promiscuous Akt: PI(3,4,5)P3 binding controls Akt activity in cells. Brendan D. Manning, T.H. Chan School of Public Health, Harvard
11:10-11:35 am- Spatial control of ubiquitin signals underlying mitophagy. Wade Harper, Harvard Medical School
11:35 am-12:00 pm- A proximity map of a human cell. Anne-Claude Gingras, Lunenfeld-Tanenbaum Research Institute
12:00-12:25 pm- Phenotypic Profiling in Yeast Using High-content Screening and Automated Image Analysis. Brenda Andrews, University of Toronto
12:25-12:30 pm- Concluding remarks

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