ASCB Rainbow

Subgroup F

Subgroup F: Optogenetics: From Molecular Switches to (Multi-)Cellular Circuits

8:30 am – 12:30 pm, Room 113C
Organizers: Harald Janovjak, IST Austria; and Jared Toettcher, Princeton University

Optogenetics is an emerging method that employs light to control the behavior of selected cells and tissues. The use of light permits transient and local regulation of processes on short time and small length scales and opens the door to dissect cause-consequence relationships that govern cell, tissue and organism function. In this subgroup session, we will cover all aspects relevant to this emerging and multi-disciplinary field, including the origins and diversity of photoreceptors, design of optogenetic tools and experiments and strategies to dissect (multi-)cellular circuits in a variety of systems. This subgroup session will place emphasis on seminal and unpublished work and accessibility to a broad audience and thereby inform on most recent research, inspire future developments and connect prospect collaborators.


8:30-8:35 am- Introduction. Harald Janovjak, IST Austria; and Jared Toettcher, Princeton University
8:35-9:00 am- Engineered protein responses – allostery and optogenetics. Klaus Hahn, University of North Carolina Chapel Hill
9:00-9:25 am- Near-infrared optogenetic tools designed from bacterial phytochromes. Vladislav Verkhusha, Albert Einstein College of Medicine
9:25-9:50 am- Engineering the bacterial transcriptional regulator AraC to make it light-responsive. Barbara di Ventura, University of Freiburg
9:50-10:05 am- Optical dissection of class C G protein-coupled receptors. Josh Levitz, Weill Cornell Medicine
10:05-10:20 am- Multi-color and bi-directional control of membrane receptor signaling. Eva Reichhart, IST Austria
10:20-10:30 am- Break
10:30-10:55 am- Expanding the boundaries of photosensory proteins as optogenetic tools. Brian Chow, University of Pennsylvania
10:55-11:20 am- Using optogenetics to control engineered metabolisms. Jose Avalos, Princeton University
11:20-11:45 am- Synthetic morphogenesis in naïve embryonic tissues. Stefano de Renzis, EMBL Heidelberg
11:45 am-12:00 pm- Real-time visualization and optogenetic regulation of transcription in single cells. Andreas Milias-Argeitis, University of Groningen
12:00-12:15 pm- Cracking the code: Ras/Erk interpretation by immediate-early genes. Max Wilson, Princeton University
12:15-12:30 pm- General Questions and Answers / Closing Remarks

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