ASCB Rainbow

Subgroup C

Subgroup C: Cell Biology in Adaptive Immune Response

8:30 am – 12:30 pm, Room 113B
Organizers: Xiaolei Su, University of California, San Francisco; and Jonathon Ditlev, UT Southwestern Medical Center

The adaptive immune system guards our body against pathogen attacks and creates long-term memory of immunity. It also kills tumors and can be reprogramed and engineered for advanced cancer therapies. Although functions and surface markers of the players in adaptive immunity (e.g. T cell, B cell, Dendritic cell) have been well studied, the intracellular processes that mediate these cells’ responding to and processing pathogenic stimuli remain much less understood. This subgroup highlights recent progress in understanding the cell biological mechanisms underlying immune cell activation. We aim to promote the interactions between the immunology and cell biology communities, benefiting each other through stimulating discussions on commonly interested topics.


8:30-8:35 am-  Introduction. Xiaolei Su, University of California, San Francisco
8:35-8:55 am- Phase Transition in T Cell Activation. Xiaolei Su, University of California, San Francisco
8:55-9:15 am- MHC class II Antigen-processing Chaperones, HLA-DM and HLA-DO, Cooperate and Select Immunodominant Epitopes for Presentation to CD4+ T cells in Thymus and B cells. Scheherazade Sadegh-Nasseri, Johns Hopkins University
9:15-9:35 am- A Phosphatidylinositol 4, 5-Biphosphate (PIP2) Metabolism-Derived Amplification Loop Fuels the Sustained Transmembrane Signaling. Wanli Liu, Tsinghua University
9:35-9:55 pm- STIM-Mediated Control of Calcium Entry and Clearance at the Immunological Synapse. Jonathan Soboloff, Temple University
9:55-10:15 am- Signaling and Cell Biology of TIM Family Proteins. Lawrence Kane, University of Pittsburgh
10:15 am- Break
10:30-10:50 am- Insights into Immune Cell Signaling from Germline and Somatic CARD11 Mutations. Joel Pomerantz, Johns Hopkins University
10:50-11:10 am- Composition of LAT Clusters Regulates Their Movement within Actomyosin Networks. Jonathon Ditlev, UT Southwestern Medical Center
11:10-11:30 am- An Actomyosin Network Revealed by SIM Imaging Promotes the Activation of T Cells in a Ligand-Dependent Manner. John Hammer, National Institutes of Health
11:30-11:50 am- Cytoskeletal Crosstalk at the Immunological Synapse. Janis Burkhardt, University of Pennsylvania
11:50 am-12:10 pm- Mechanical Enhancement of Cytotoxic T Cell Killing. Morgan Huse, Memorial Sloan Kettering Cancer Center
12:10-12:30 pm- The Role of Ubiquitination at the Immune Synapse. James Muller, New York University

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