Minisymposium 8: Cancer Cell Signaling, Adaptive Responses, and Metastasis
Chair: Brendan D. Manning, Harvard University
Supported by Thermo Fisher Scientific Inc.
4:15 pm Introduction
4:20 pm M79 Centrosome amplification triggers a non-canonical Senescence-Associated Secretory Phenotype and HIF1-α activation. S.K. Wu1,2, R. Picone1,2, M.S. Levine3, S. Papathanasiou1,2, M. Kwon1,2, M. Janiszewska1,2, K. Polyak1, A. Spektor1,2, A.J. Holland3, D. Pellman1,2; 1Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, 2Cell Biology, Harvard Medical School, Boston, MA, 3Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, MD
4:35 pm M80 Extensive genetic and transcriptional variation alters the response of cancer cell lines to anticancer drugs. U. Ben-David1, B. Siranosian1, G. Ha1,2, H. Tang1, A. Thorner2, J. Bittker1, R. Beroukhim1,2, T.R. Golub1,2; 1Broad Institute of Harvard and MIT, Cambridge, MA, 2Dana Farber Cancer Institute, Boston, MA
4:50 pm M81 The mTOR network: signal integration and metabolic regulation. B.D. Manning1; 1Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA
5:05 pm M82 Macropinosomes Coordinate the Activation of PI3Kβ by Gβγ and Rac. Z. Erami1, B.D. Khalil1, G.K. Salloum1, Y. Yao1, A. Shymanets2, B. Nuernberg2, A.R. Bresnick3, J.M. Backer1; 1Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 2Institute for Pharmacology and Toxicology, Eberhard-Karls-Universität Tübingen, Tubingen, Germany, 3Biochemistry, Albert Einstein College of Medicine, Bronx, NY
5:20 pm M83 Endosomal/autophagic regulation of FOXO transcription factors. I. Meras1, L. Chotardd2, C.E. Rocheleau1,2; 1Anatomy and Cell Biology , McGill University, Montreal , QC, 2Research Institute of the McGill University, McGill University , Montreal, QC
5:35 pm M84 Hypoxia and cancer stem cell activity are linked during tumor cell dissemination and metastasis in breast tumors. E. Xue1, V.P. Sharma1,2, D. Entenberg1,2,3, Y. Wang1,2,3, B. Tang4, L. Wakefield4, M.H. Oktay1,2,3,5, J.S. Condeelis1,2,3; 1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, 2Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY, 3Integrated Imaging Program, Albert Einstein College of Medicine, Bronx, NY, 4Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD, 5Department of Pathology, Albert Einstein College of Medicine, Bronx, NY
5:50 pm M85 Identification of RAN binding protein 6 (RanBP6) as an EGFR feedback regulator and a tumor suppressor in glioblastoma. W. Hsieh1,2, B. Oldrini1,3, H. Erdjument-Bromage4, P. Codega1, M.S. Carro5, C. Campos1, B.S. Taylor1,6, P. Tempst1, M. Squatrito3, I.K. Mellinghoff1,7; 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, 2Department of Pharmacology, Weill Cornell Medical College, New York, NY, 3Seve Ballesteros Foundation Brain Tumor Group, National Cancer Research Centre (CNIO), Madrid, Spain, 4Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 5Department of Neurosurgery, Medical Center University of Freiburg, Freiburg, Germany, 6Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, 7Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY
6:05 pm M86 Nedd9 influences lung cancer tumorigenesis through regulation of autophagy. A.Y. Deneka1,2, M.C. Kopp3, A.S. Nikonova1, L. Haber1, A. Gaponova1, A. Nagele1, H. Hensley1, E.A. Golemis1; 1Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, PA, 2Biochemistry, Kazan Federal University, Kazan, Russia, 3Pulmonary, Allergy and Critical Care , University of Pennsylvania, Philadelphia, PA
6:20 pm M87 Dietary conjugated polyunsaturated fatty acids induce ferroptotic cell death and suppress breast cancer tumorigenesis and metastasis. A.C. Beatty1, L.S. Fink1, A. Strigun2, T. Singh1, E. Peter1, C. Ferrer3, E. Nicolas1, K.Q. Cai1, T.P. Moran1, M.J. Reginato3, U. Rennefahrt2, J.R. Peterson1; 1Cancer Biology, Fox Chase Cancer Center, Philadelphia, PA, 2Metanomics GmbH & Metanomics Health GmbH, Berlin, Germany, 3Drexel University, Philadelphia, PA
6:35 pm M88 Distinct ECM proteins of breast cancer metastatic niches in multiple organs. J.D. Hebert1, S.A. Myers2, A. Naba1, K.R. Clauser2, S.A. Carr2, R.O. Hynes1; 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 2Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA
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