ASCB Rainbow

Minisymposium 7

Minisymposium 7: Actin Dynamics and Function

4:15-6:50 pm
Room 113B
Co-Chairs: Stephanie Gupton, University of North Carolina at Chapel Hill; and Kenneth Campellone, University of Connecticut

4:15 pm       Introduction

4:20 pm   M69    Direct observation of actin structural deformation in response to mechanical force. P.S. Gurel1, Y. Takagi2, J.E. Bird3, J.R. Sellers2, G.M. Alushin1; 1The Rockefeller University, New York, NY, 2Cellular Biology and Physiology Center, National Heart, Lung, and Blood Institute, Bethesda, MD, 3National Institute of Deafness and Other Communication Diseases, Bethesda, MD

4:35 pm   M70    Twinfilin promotes Capping Protein association with actin filament barbed ends by attenuating the inhibitory effects of CARMIL. D. Hilton1, A. Johnston1, A. Simone1, P. McConnell2, J.A. Cooper2, B.L. Goode1; 1Molecular  Cellular Biology, Brandeis University, Waltham, MA, 2Biochemistry  Molec Biophysic, Washington University in St. Louis, St. Louis, MO

4:50 pm   M71    Arp2/3 complex- and formin-mediated actin networks tune actin-binding protein sorting in fission yeast. K.E. Homa1, C. Suarez1, D.R. Kovar1,2; 1Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL, 2Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL

5:05 pm   M72    CYRIPS (Fam49) proteins are local inhibitors of Rac1 and Scar/WAVE induced lamellipodia. L. Fort1, J. Batista1, P. Thomason1, H. Spence1, J. Greaves2, K. Martin1, K. Anderson1,3, P. Brown1, S. Lilla1, M. Nielson1, P. Tafelmeyer4, S. Zanivan1, S. Ismail1, N. Tomkinson5, L.H. Chamberlain2, R.H. Insall1, L.M. Machesky1; 1Beatson Institute for Cancer research, Glasgow, United Kingdom, 2Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom, 3Crick Institute, London, United Kingdom, 4Hybrigenics Services, Paris, France, 5WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, United Kingdom

5:20 pm   M73    Ubiquitin-dependent regulation of filopodia during axon guidance and branching. N. Boyer1, C. Monkiewicz2, S. Menon2, S.L. Gupton2,3; 1Neurobiology Curriculum, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC, 2Cell Biology and Physiology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC, 3Neuroscience Center, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC

5:35 pm   M74    Mechanistic principles underlying regulation of the actin cytoskeleton by phosphoinositides. Y. Senju1, M. Kalimeri2, E. Koskela1, P. Somerharju3, H. Zhao1, I. Vattulainen2,4, P. Lappalainen1; 1Institute of Biotechnology, University of Helsinki, Helsinki, Finland, 2Department of Physics, Tampere University of Technology, Tampere, Finland, 3Faculty of Medicine, University of Helsinki, Helsinki, Finland, 4Department of Physics, University of Helsinki, Helsinki, Finland

5:50 pm   M75    An Amish founder mutation disrupts a PI(3)P-WHAMM-Arp2/3 complex driven autophagosome remodeling pathway. A. Mathiowetz1, E. Baple2, A. Russo1, A. Coulter1, E. Carrano1, J. Brown1, R. Jinks3, A. Crosby2, K. Campellone1; 1University of Connecticut, Storrs, CT, 2University of Exeter Medical School, Exeter, United Kingdom, 3Franklin and Marshall College, Lancaster, PA

6:05 pm   M76    Complement mediated phagocytosis involves mechanical coupling of β2 integrins to the actin cytoskeleton by a myosin-independent molecular clutch. V. Jaumouillé1, T. Liu2, E. Betzig2, C.M. Waterman1; 1National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 2Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA

6:20 pm   M77    A geodesic septin lattice is required for actomyosin contractility on micron-scale curved membranes in vivo. S. Ebrahim1, A. Shitara1, H. Shroff2, B. Kachar3, R. Weigert1; 1NCI, NIH, Bethesda, MD, 2NIBIB, NIH, Bethesda, MD, 3NIDCD, NIH, Bethesda, MD

6:35 pm   M78    The interaction of FHOD1 with nesprin-2G activates a cryptic actin binding site and stimulates potent actin bundling activity: implications for nuclear movement.  S. Antoku1, G.G. Gundersen1; 1Pathology & Cell Biology, Columbia University, New York, NY

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