ASCB Rainbow

Minisymposium 25

Minisymposium 25: Visualization of Compartmentalized Signaling in Cancer

8:30-11:05 am
Room 115B
Co-Chairs: Peter S. McPherson, Montreal Neurological Institute, McGill University; and Min Wu, National University of Singapore

8:30 am       Introduction

8:35 am   M249    The lateral mobility of membrane-tethered KRAS4b revealed spatiotemporal complexity of signaling. D. Goswami1,2,3,4, D. Chen1,2,3,4, J. Columbus1,2,3,4, T.J. Turbyville1,2,3,4; 1Frederick National Laboratory for Cancer Research, Frederick, MD, 2National Cancer Institute, Frederick, MD, 3Cancer Research Technology Program, Frederick, MD, 4Leidos Biomedical Research, Inc., Frederick, MD

8:50 am   M250    Engineering Cell Sensing and Responses Using a GPCR-Coupled CRISPR-Cas System. P.P. Dingal1,2,3, N.H. Kipniss1, L. Labanieh1, Y. Gao4, L.S. Qi1,2,3; 1Bioengineering, Stanford University, Stanford, CA, 2ChEM-H, Stanford University, Stanford, CA, 3Chemical & Systems Biology, Stanford University, Stanford, CA, 4Cancer Biology Program, Stanford University, Stanford, CA

9:05 am   M251    Divergence in the temporal dynamics of Extracellular-signal regulated kinase (ERK) activity between subcellular compartments. J.D. Keyes1, A. Ganesan2, J. Zhang1,2; 1Pharmacology, University of California San Diego, San Diego, CA, 2Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD

9:20 am   M252    Information content of the single cell cortical travelling waves. D. Xiong1,2,3, S. Xiao1,2, C. Tong1,2, M. Wu1,2,3; 1 Department of Biological Sciences, National University of Singapore, Singapore, Singapore, 2Centre for Bioimaging Sciences, National University of Singapore, Singapore, Singapore, 3Mechanobiology Institute, National University of Singapore, Singapore, Singapore

9:35 am   M253    Intersectin-s interaction with the Rab13 exchange factor DENND2B facilitates recycling of epidermal growth factor receptor. M.S. Ioannou1, G. Kulasekaran1, M. Fotouhi1, J.J. Morein1, C. Han1, S. Tse1, N. Nossova1, T. Han1, E. Mannard1, P.S. McPherson1; 1Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC

9:50 am   M254    Engineered Allosteric Regulation of Protein Kinases by Light. M. Shaaya1, V. Huyot1, V. Natarajan1, A.V. Karginov1; 1Cellular and Molecular Pharmacology, University of Illinois at Chicago, Chicago, IL

10:05 am   M255    High resolution in vivo imaging of cancer cell extravasation. T. Liu1, V. Singh1, E. Betzig1, D.Q. Matus2, B.L. Martin2; 1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, 2Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY

10:20 am   M256    Oscillatory HIF-1α induction promotes proliferation of hypoxic cells through a lactate dependent quorum autophagy response. Kshitiz1,2, J. Afzal2, H. Chang1, Y. Suhail2, M. Hubbi2, C. Dang2,3, A. Levchenko1; 1Biomedical Engineering, Yale University, New Haven, CT, 2Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, 3Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA

10:35 am   M257    Endocytosis and PTEN in Tumor Suppression. M. Lee1, A. Naguib1, L.C. Trotman1, N. El-Amine1; 1Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

10:50 am   M258    Plasma Membrane PI(4,5)P2 Threshold Regulates Cell Migration Speed and Morphology. M. Beshay1, N. Bawazir1, J. Notino1, C. Janetopoulos1; 1Biological Sciences, University of the Sciences in Philadelphia, Philadelphia, PA

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