ASCB Rainbow

Minisymposium 22

Minisymposium 22: Cellular Metabolism

8:30-11:05 am
Room 120B
Co-Chairs: Nika Danial, Dana-Farber Cancer Institute, Harvard Medical School; and Russell DeBose-Boyd, University of Texas Southwestern Medical Center

8:30 am       Introduction

8:35 am   M219    Geranylgeranyl-Regulated, ER-to-Golgi Transport of UBIAD1: Implications for Cholesterol Homeostasis and Schnyder Corneal Dystrophy. R.A. DeBose-Boyd1; 1Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX

*8:50 am   M220    Genetic depletion of adipocyte creatine metabolism inhibits diet-induced thermogenesis and drives obesity. L. Kazak1, G.Z. Lu1, E.T. Chouchani1, B.M. Spiegelman1; 1Cancer Biology, Dana-Farber Cancer Institute, Boston, MA

9:05 am   M221    Molecular mechanisms of Scavenger Receptor SR-BI regulation: linking HDL binding to cholesterol transport. P.E. Marques1, S. Nyegaard1, R.F. Collins1, W.S. Trimble1, S. Grinstein1; 1Cell Biology, The Hospital for Sick Children, Toronto, ON

9:20 am   M222    Mitochondrial Calcium Uniporter controls AMPK activity and lipid metabolism. D. Tomar1,2, F. Jaña1, Z. Dong1,2, N. Nemani1,2, S. Santhanam1,2, A. Tripathi1,2, E. Carvalho1,2, S. Rajan1,2, D.S. Wijesinghe3, R.S. Ahima4, M. Madesh1,2; 1Center for Translational Medicine, Temple University, Philadelphia, PA, 2Department of Medical Genetics  Molecular Biochemistry, Temple University, Philadelphia, PA, 3Department of Surgery, Virginia Commonwealth University, Richmond, VA, 4Division of Endocrinology, Diabetes and Metabolism, John Hopkins University, Baltimore, MD

9:35 am   M223    Regulation of adipose tissue metabolism via non-proteolytic ubiquitination and mitochondria retrograde signaling. M.D. Cardamone1, C.T. Cederquist1, B. Tanasa2,3, J. Huang1, K. Mahdaviani4, C. Lentucci1, W. Li2,5, M.G. Rosenfeld2, M. Liesa4,6, V. Perissi1; 1Biochemistry, Boston University, Boston, MA, 2Medicine, UCSD, La Jolla, CA, 3Pediatrics, Stanford University, San Francisco, CA, 4Medicine, Boston University, Boston, MA, 5Biochemistry and Molecular Biology, UT Health McGovern Medical School, Houston, TX, 6Medicine, UCLA, Los Angeles, CA

9:50 am   M224    Aerobic Respiration Enhanced by Mitochondrial Fusion Remodels Vacuolar Liquid-ordered Membrane Domain to Induce Micro-lipophagy for Cell Survival during Glucose Restriction.  A.Y. Seo1, F. Sarkleti2, C.A. Larabell3, J. Lippincott-Schwartz1; 1Janelia Research Campus, HHMI, Ashburn, VA, 2Institute of Molecular Biosciences, University of Graz, Graz, Australia, 3Department of Anatomy, University of California San Francisco, San Francisco, CA

10:05 am   M225    Regulated assembly of a macromolecular complex of IMPDH during T cell activation. K.C. Duong-Ly1, S.A. Anthony1, A.L. Burrell2, M.C. Johnson2, Y. Kuo3, J.C. Simonet1, P. Michener4, J. Soboloff5, G. Rall6, A. Andrews3, J.M. Kollman2, J.R. Peterson1; 1Cancer Biology, Fox Chase Cancer Center, Philadelphia, PA, 2Biochemistry, University of Washington, Seattle, WA, 3Cancer Epigenetics, Fox Chase Cancer Center, Philadelphia, PA, 4Biochemistry  Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, 5Felt Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, 6Blood Cell Development and Function, Fox Chase Cancer Center, Philadelphia, PA

10:20 am   M226    Prolyl dihydroxylation of extra-ribosomal Rps23/uS12 regulates hypoxic adaptation in fission yeast. S.J. Clasen1, W. Shao1, H. Gu1, P.J. Espenshade1; 1Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD

10:35 am   M227    Mutation of dgat2 uncouples lipolysis and lipoprotein synthesis in the zebrafish embryonic digestive organ resulting in excess ectopic lipid droplets. M.H. Wilson1, J.H. Thierer1,2, S.A. Farber1,2; 1Embryology, Carnegie Institution for Science, Baltimore, MD, 2Biology, The Johns Hopkins University , Baltimore, MD

10:50 am   M228    Metabolic control of beta-cell survival. N.N. Danial1; 1Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

*Lawrence Kazak is the 2017 Merton Bernfield Awardee.

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