ASCB Rainbow

Minisymposium 21

Minisymposium 21: Border Dynamics: Nuclear Envelope Organization and Remodeling

8:30-11:05 am
Room 114
Co-Chairs: Martin Beck, European Molecular Biology Laboratory (EMBL), Germany; and Ulrike Kutay, ETH Zurich, Switzerland

8:30 am       Introduction

8:35 am   M209    In situ structural analysis of the nuclear pore complex. M. Beck1; 1Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany

8:50 am   M210    DNA-origami based platforms reveal mobility of FG-nups within nuclear pore complex-like architectures. Q. Shen1, P. Ellis1, B. Akpinar2, T.J. Melia1, B. Hoogenboom2, C. Lin1, P. Lusk1; 1Cell Biology, Yale School of Medicine, New Haven, CT, 2London Centre for Nanotechnology, London, United Kingdom

9:05 am   M211    Transcription factor-mediated targeting of genes to the nuclear pore complex is the major pathway controlling peripheral localization of genes in budding yeast. D. Brickner1, M. LeBrun1, C.R. Hinchliff1, J.H. Brickner1; 1Molecular Biosciences, Northwestern University, Evanston, IL

9:20 am   M212    Lamin mutations linked to muscular disease result in mechanically-induced, progressive nuclear envelope rupture and DNA damage in muscle fibers. A. Earle1, T.J. Kirby2, G.R. Fedorchak1, P. Isermann2, J. Lammerding1,2; 1Biomedical Engineering, Cornell University, Ithaca, NY, 2Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY

9:35 am   M213    Mechano-protection by lamin-A against DNA damage as the developing heart stiffens and strengthens. S. Cho1, S. Majkut2, A. Abbas1, K. Vogel1, M. Vashisth1, J. Irianto1, M. Tewari1, B.L. Prosser3, D.E. Discher1; 1Molecular & Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA, 2Department of Physics & Astronomy, University of Pennsylvania, Philadelphia, PA, 3Department of Physiology, Pennsylvania Muscle Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

9:50 am   M214    Evolution of mitotic nuclear envelope dynamics through Lem2-ESCRT-III/Vps4 interaction. G. Pieper1,2, S. Sprenger3, D. Teis3, S. Oliferenko1,2; 1Francis Crick Institute, London, United Kingdom, 2Randall Division of Cell and Molecular Biophysics, King’s College London, London, United Kingdom, 3Division of Cell Biology, Medical University of Innsbruck, Innsbruck, Austria

10:05 am   M215    Dual spindle formation around zygotic pro-nuclei explains parental genome separation. J. Reichmann1, B. Nijmeijer1, J.M. Hossain1, M. Eguren1, I. Schneider1, A.Z. Politi1, L. Hufnagel1, T. Hiiragi2, J. Ellenberg1; 1Cell Biology and Biophysics, The European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 2Developmental Biology, The European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

10:20 am   M216    Mixing of parental genomes after fertilization in C. elegans involves fusion and fenestration of pronuclear membranes. M.M. Rahman1, I. Chang2, A.S. Harned2, K. Narayan2, O. Cohen-Fix1; 1Laboratory of Cell  Molecular Biology, National Institute of Diabetes  Digestive & Kidney Diseases, Bethesda, MD, 2Center for Molecular Microscopy, Frederick National Laboratories for Cancer Research, Frederick, MD

10:35 am   M217    The coordination of chromosome segregation and nuclear envelope assembly: implications for nuclear envelope integrity and genome stability. S. Liu1,2, M. Kwon1,2, N. Yang3, A. Khodjakov3,4, D. Pellman1,2,5; 1Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, 2Department of Cell Biology, Harvard Medical School, Boston, MA, 3Wadsworth Center, New York State Department of Health, Albany, NY, 4Rensselaer Polytechnic Institute, Troy, NY, 5Howard Hughes Medical Institute, Boston, MA

10:50 am   M218    Taking Apart the Nuclear Envelope during Open Mitosis. U. Kutay1; 1Institute of Biochemsitry, ETH Zurich, Zurich, Switzerland

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