ASCB Rainbow

Minisymposium 2

Minisymposium 2: Functions and Mechanisms of Cytoskeletal Motors

4:15-6:50 pm
Room 113B
Co-Chairs: Arne Gennerich, Albert Einstein College of Medicine; and Andrew Carter, MRC Laboratory of Molecular Biology

4:15 pm       Introduction

4:20 pm   M11    Mitochondria distribution to filopodia by the actin-based motor Myo19. B.I. Shneyer1, M. Usaj1, N. Wiesel-Motiuk1, R. Regev1, A. Henn1; 1Biology, Technion-Israel Institute of Technology, Haifa, Israel

4:35 pm   M12    The 3.5Å cryoEM structure of a fast dynein/dynein complex. L. Urnavicius1, C.K. Lau1, M.M. Elshenawy2, E. Morales1, A. Yildiz2, A.P. Carter1; 1MRC LMB, Cambridge, United Kingdom, 2UC Berkeley, Berkeley, CA

4:50 pm   M13    KIFC1, a mitotic motor protein expressed throughout the life of the neuron, is enriched in the distal region of the axon where it crosslinks microtubules in a manner that opposes axon retraction. H. Muralidharan1, X. Sun1, P.W. Baas1; 1Neurobiology & Anatomy, Drexel University College of Medicine, Philadelphia, PA

5:05 pm   M14    Molecular mechanism of dynein’s direction-dependent microtubule-binding strength. L. Rao1, F. Berger2, M.P. Nicholas1, A. Gennerich1; 1Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, 2Rockefeller University, New York, NY

5:20 pm   M15    Myosin IIA controls red blood cell membrane morphology and mechanical properties. A.S. Smith1, R.B. Nowak1, S. Zhou2, J. Wan2, I.C. Ghiran3, V.M. Fowler1; 1Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 2Microsystems Engineering, Rochester Institute of Technology, Rochester, NY, 3Medicine, Beth Israel Deaconess Medical Center, Boston, MA

5:35 pm   M16    IDA3 associates with IFT in growing cilia to selectively mediate transport and assembly of axonemal I1 dynein. E.L. Hunter1, J. Hwang1, G. Fu2, L.M. Alford3, A. Gokhale1, R. Yamamoto4, R. Kamiya5, H. Lin6, F. Yang7, D. Nicastro2, K.F. Lechtreck8, M. Wirschell7, S.K. Dutcher6, W.S. Sale1; 1Department of Cell Biology, Emory University, Atlanta, GA, 2Department of Cell Biology and Biophysics, UT Southwestern Medical Center, Dallas, TX, 3Department of Biology, Oglethorpe University , Atlanta , GA, 4Department of Biological Sciences, Osaka University, Osaka, Japan, 5Department of Biological Sciences, Chuo University, Tokyo, Japan, 6Department of Genetics, Washington University School of Medicine, St. Louis, MO, 7Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS, 8Department of Cellular Biology, University of Georgia, Athens, GA

5:50 pm   M17    Kinesin-2 motors adapted their stepping behaviour for progressive transport on axonemes and microtubules. W. Stepp1, G. Merck1, F. Mueller-Planitz2, Z. Ökten1,3; 1Department für Physik, Technische Universität München, Munich, Germany, 2Biomedical Center, Ludwigs Maximilians Universität, Munich, Germany, 3Munich Center for Integrated Protein Science, Munich, Germany

6:05 pm   M18    She1 affects dynein by interactions with the microtubule and the dynein microtubule-binding domain. K. Ecklund1, T. Morisaki1, L.G. Lammers1, M.G. Marzo1, T.J. Stasevich1, S.M. Markus1; 1Biochemistry & Molecular Biology, Colorado State University, Fort Collins, CO

6:20 pm   M19    Regulated autoinhibition of kinesin-1 is essential to polarized dendritic transport. M.T. Kelliher1, Y. Yue2, A. Ng1, D. Kamiyama3, B. Huang4, K.J. Verhey2, J. Wildonger1; 1Biochemistry, University of Wisconsin – Madison, Madison, WI, 2Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 3Cellular Biology, University of Georgia, Athens, GA, 4Department of Pharmaceutical Chemistry, University of California – San Francisco, San Francisco, CA

6:35 pm   M20    CDK5-dependent activation of dynein in the axon initial segment regulates polarized cargo transport in neurons. E. Klinman1, M. Tokito2, E.L. Holzbaur2; 1Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2Physiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

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