ASCB Rainbow

Minisymposium 18

Minisymposium 18: Molecular Mechanisms of Cell-Cell Signaling

4:40-7:15 pm
Room 115B
Co-Chairs: Adrian Salic, Harvard Medical School; and Natalia Jura, University of California, San Francisco

4:40 pm       Introduction

4:45 pm   M179    STK25 Activates the LATS Kinases to Inhibit YAP/TAZ. S. Lim1, N.J. Ganem1,2; 1Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, 2Medicine, Boston University School of Medicine, Boston, MA

5:00 pm   M180    Mechanism of T cell receptor signal transduction by phase transition. X. Su1, J.A. Ditlev2, E. Hui1, S. Banjade2, M.K. Rosen2, R.D. Vale1; 1CMP, UCSF/HHMI, San Francisco, CA, 2Biophysics, UT Southwestern/HHMI, Dallas, TX

5:15 pm   M181    A conserved, transposable ubiquitination signal directs Ras for inhibitory ubiquitination by Rabex-5 and is mutated in tumors. C. Washington1,2, Y. Martino-Cortez1,3, S. Shahar1, H. Liu1,4, R. Gokhale1, C.M. Pfleger1; 1Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 2University of Cincinnati College of Medicine, Cincinnati, OH, 3Tufts University School of Medicine, Boston, MA, 4Memorial Sloan Kettering Cancer Center, New York, NY

5:30 pm   M182    APC regulates Wnt signaling by inhibiting a constitutive clathrin-mediated activation pathway. K. Saito-Diaz1, H. Benchabane2, A. Tiwari1, B. Li3, A. Tian2, L.M. Sawyer1, A.S. Hyde1, A.K. Kenworthy1, D. Robbins3, Y. Ahmed2, E. Lee1; 1Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, 2Department of Molecular and Systems Biology, Dartmouth College, Hanover, NH, 3Department of Surgery, University of Miami, Miami, FL

5:45 pm   M183    Cholesterol-dependent regulation of the oncoprotein Smoothened during Hedgehog signaling. P. Huang1, A. Salic1; 1Cell Biology, Harvard Medical School, Boston, MA

6:00 pm   M184    Defining the structure and stoichiometry of the Wnt-regulatory destruction complex during normal development and the mechanisms by which the complex is regulated by Wnt signaling. K. Schaefer1, S. Zhang2, T.T. Bonello2, C. Williams2, D.J. Mckay1,2, M. Peifer1,2,3; 1Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 2Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 3Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC

6:15 pm   M185    Activating RASopathy mutations lead to both gain and loss of function phenotypes in vivo. G.A. Jindal1,2,3, Y. Goyal2,3, V.L. Patterson1, J.L. Pelliccia1, E. Yeung2,3, G.M. Schupbach1, S.Y. Shvartsman1,2,3, R.D. Burdine1; 1Molecular Biology, Princeton University, Princeton, NJ, 2Chemical and Biological Engineering, Princeton University, Princeton, NJ, 3The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ

6:30 pm   M186    The Semaphorin receptors, Neuropilins and Plexins, promote Hedgehog signaling through distinct cytoplasmic mechanisms. J.M. Pinskey1, N.E. Franks1, R.J. Giger1, B.L. Allen1; 1Cell and Developmental Biology, University of Michigan, Ann Arbor, MI

6:45 pm   M187    Polymerization of the mitochondrial phosphatase PGAM5 underlies its biological activity. K. Ruiz1, T.M. Thaker1, L. Miller-Vedam2, C. Agnew1, A. Frost2, N. Jura1,3; 1Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, 2Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, 3Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA

7:00 pm   M188    ER translocation of the entire MAPK pathway drives ERK reactivation and autophagy to promote therapy resistance in BRAF mutant cancers. R. Ojha1, N.M. Leli2, A. Onorati1, I. Verginadis2, S. Piao1, F. Tameire2, V. Rebecca1, C. Fennelly1, C.I. Chude1, C.  Koumenis1, R.K.  Amaravadi1; 1Division of Hematology and Oncology, University of Pennsylvania, Philadelphia , PA, 2Department of Radiation Oncology, Smilow Center for Translational Research, University of Pennsylvania, Philadelphia , PA

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