ASCB Rainbow

Minisymposium 12

Minisymposium 12: Protein Folding, Misfolding and Neurodegeneration

4:15-6:50 pm
Room 118B

Supported by BMC Biology

Co-Chairs: Ursula Jakob, University of Michigan and University of Michigan Medical School; and Simon Alberti, Max Planck Institute of Molecular Cell Biology and Genetics, Germany

4:15 pm       Introduction

4:20 pm   M119    Prion-specific Hsp40 functions promote amyloid diversity in yeast: reciprocal roles for J-proteins in promoting and preventing amyloid elimination. J.K. Hines1; 1Chemistry, Lafayette College, Easton, PA

4:35 pm   M120    Potentiated Hsp104 Variants to Counter Protein Misfolding. M.E. Jackrel1; 1Chemistry, Washington University, St. Louis, MO

4:50 pm   M121    Role of Polyphosphate in Amyloidogenic Processes. U. Jakob1, C.M. Cremers1, D. Knoefler1, M.J. Gray1, N. Yoo1, J. Dahl1, L. Xie1, J. Lempart1; 1MCDB, University of Michigan, Ann Arbor, MI

5:05 pm   M122    Rapid heat-shock response depends on intracellular pH. C.G. Triandafillou1, A.R. Dinner2, D.A. Drummond3; 1Biophysical Sciences Graduate Program, University of Chicago, Chicago, IL, 2James Franck Institute, University of Chicago, Chicago, IL, 3Biochemistry and Molecular Biology, University of Chicago, Chicago, IL

5:20 pm   M123    A prion domain that promotes cellular fitness by pH-regulated protein phase separation. T. Franzmann1, M. Jahnel1, S.W. Grill1, A.A. Hyman1, S. Alberti1; 1Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

5:35 pm   M124    Tardigrade intrinsically disordered proteins mediate desiccation tolerance. T.C. Boothby1, S. Piszkiewicz1, A. Mehta1, A.H. Brozena2, H. Tapia3, D.E. Koshland3, A.S. Holehouse4, R.V. Pappu4, B. Goldstein5, G.J. Pielak1; 1Chemistry, UNC, Chapel Hill, NC, 2Chemical Engineering, NC State, Raleigh, NC, 3Molecular and Cell Biology, UC Berkeley, Berkeley, CA, 4Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 5Biology, UNC, Chapel Hill, NC

5:50 pm   M125    Characterization of p97 mutations causing multisystem proteinopathy support a gain-of-function model for pathology. E.E. Blythe1, A. Martin2, R.J. Deshaies1; 1Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 2Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA

6:05 pm   M126    Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration. J. Wang1, X. Han2, N.A. Leu1, S. Sterling1, S. Kurosaka1, M.E. Fina1, V.M. Lee3, D.W. Dong1,4, J. Yates III2, A.S. Kashina1; 1School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 2The Scripps Research Institute, La Jolla, CA, 3Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 4Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

6:20 pm   M127    Poly (ADP-ribose) modulates phase separation of the ALS-associated protein TDP-43. L. McGurk1, E. Gomes2, L. Guo2, J. Mojsilovic-Petrovic3, V. Tran1, R.G. Kalb3, J. Shorter2, N.M. Bonini1; 1Department of Biology, University of Pennsylvania, Philadelphia, PA, 2Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, 3Department of Neurology, Children’s Hospital of Philadelphia, Philadelphia, PA

6:35 pm   M128    Small molecules for modulating protein driven liquid-liquid phase separation in neurodegenerative disease. R.J. Wheeler1, H. Lee1, A. Pal2,3, A. Murthy4, I. Poser1, L. Marrone3, T. Doeleman2,3, J. Sterneckert3, M. Bickle1, A. Hermann2,3, S. Alberti1, A.A. Hyman1; 1Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany, 2Department of Neurology, Dresden, Germany, 3Center for Regenerative Therapies, Dresden, Germany, 4Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI

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