ASCB Rainbow

Minisymposium 10

Minisymposium 10: Lipids in Signaling and Membrane Organization

4:15-6:50 pm
Room 115B
Co-Chairs: Christopher Burd, Yale University School of Medicine;  and Maria Antonietta De Matteis, Telethon Institute of Genetics and Medicine, Italy

4:15 pm       Introduction

4:20 pm   M99    Structural determinants of raft partitioning for single-pass transmembrane proteins and their effects on subcellular localization. J.H. Lorent1, B.B. Diaz-Rohrer1, K.R. Levental1, I. Levental1; 1Integrative Biology and Pharmacology, Mc Govern Medical School at UT Health Science Center at Houston, Houston, TX

4:35 pm   M100    SNX-BAR mediated retrograde trafficking of yeast synaptobrevin/Snc1 is conferred by its transmembrane domain. M. Ma1, L. Purushothaman2, M. Babst3, C. Ungermann2, C.G. Burd1; 1Department of Cell Biology, Yale University, New Haven, CT, 2Department of Biology/Chemistry, University of Osnabrueck, Osnabrück, Germany, 3Department of Biology, University of Utah, Salt Lake City, UT

4:50 pm   M101    A role of an inositol 5-phosphatase in ER architecture. R. Dong1,2,3, T. Zhu4, L. Benedetti1,2,3, S. Gowrishankar1,2,3, H. Deng4, X. Wang4, K. Shen5,6, P. De Camilli1,2,3,7; 1Department of Neuroscience, Yale University School of Medicine, New Haven, CT, 2Department of Cell Biology, Yale University School of Medicine, New Haven, CT, 3Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, 4Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 5Department of Department of Biology and Department of Pathology , Stanford University School of Medicine, Stanford, CA, 6Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, 7Kavli Institute for Neurosciences, Yale University School of Medicine, New Haven, CT

5:05 pm   M102    Regulation of sites for organelle biogenesis at the endoplasmic reticulum. P. Carvalho1, S. Wang 1, F. Idrissi1; 1Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

5:20 pm   M103    Lipid droplet emergence from the ER membrane is mediated by phospholipids. V. Choudhary1, G. Golani2, A. Joshi1, M.M. Kozlov2, W. Prinz1; 1Laboratory of Cell and Molecular Biology, NIH/NIDDK, Bethesda, MD, 2Department of Physiology and Pharmacology, Tel Aviv University, Tel Aviv, Israel

5:35 pm   M104    Mechanism of Targeting of Amphipathic Helix-Containing Proteins to Lipid Droplets. C. Prévost1,2,3, M. Cohen4,5,6, N. Kory1,2,3, Q. Lin1,2,3, G.A. Voth4,5,6, R.V. Farese, Jr.1,2,3, T.C. Walther1,2,3,7; 1Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, 2Department of Cell Biology, Harvard Medical School, Boston, MA, 3Broad Institute of Harvard and MIT, Cambridge, MA, 4Department of Chemistry, The University of Chicago, Chicago, IL, 5James Franck Institute, The University of Chicago, Chicago, IL, 6Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, 7Howard Hughes Medical Institute, Boston, MA

5:50 pm   M105    Pattern formation and stochastic geometry sensing in a lipid kinase-phosphatase competitive reaction. S.D. Hansen1,2, W. Huang3, Y. Lee3, P. Bieling1,4, J.T. Groves1,3; 1California Institute for Quantitative Biosciences, University of California Berkeley, Berkeley, CA, 2Chemistry and Biochemistry, University of Oregon, Eugene, OR, 3Chemistry, University of California Berkeley, Berkeley, CA, 4Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany

6:05 pm   M106    ER-Golgi contact sites are maintained through redundant and essential roles of ORPs and use FAPP1 to control Golgi PI4P. R. Venditti*1, M.C. Masone*1, L.R. Rega*1, M. Santoro1, G. Di Tullio1, E.V. Polishchuk1, R. La Montagna1, M. De Matteis1,2; 1TIGEM, Telethon Foundation, Pozzuoli, Italy, 2Molecular Medicine and Medical Biotechnology, Federico II University, Naples, Italy

6:20 pm   M107    PI(4,5)P2 controls the level of its precursor, PI4P, in the plasma membrane by regulating PI4P/PS transport at ER-plasma membrane contact sites. M. Sohn1, M. Korzeniowski1, G. Hammond2, E. Boura3, T. Balla1; 1National Institute of Child Health and Human Development, National Institutes of Health, Bethesda , MD, 2Department of Cell Biology , University of Pittsburg, Pittsburg, PA, 3Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague , Czech Republic

6:35 pm   M108    SAC1 degrades its lipid substrate PtdIns4P in the ER to maintain a steep electrochemical gradient on donor membranes. J.P. Zewe1, S.J. Sangappa1, R.C. Wills1, B. Goulden1, G.R. Hammond1; 1Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA

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