ASCB Rainbow

Microsymposium 14

Microsymposium 14: Cell Metabolism

11:00 am-12:10 pm
Microsymposia Room 2, Learning Center, Hall C
Moderators: Gaia Cantelli, Duke University; and Peter Yu, Ohio State University

11:00 am   E92    The tumor suppressor Lkb1 controls cell fate through pyruvate-alanine transamination. A.G. Radu1,2, S. Torch1,2, F. Fauvelle3, P. Hainaut1, L. Larue4, C. Thibert1,5, M. Billaud5,6; 1Tumor molecular pathology and biomarkers, Institute for Advanced Biosciences, INSERM/UJF U1209 , Grenoble, France, 2cofirst authors , Grenoble, France, 3MRI Facility IRMage, Grenoble Neurosciences Institut , INSERM/CEA U817, Grenoble, France, 4Normal and Pathological Development of Melanocytes, Institut Curie, CNRS  UMR3347; INSERM U1021, Orsay, France, 5co-senior and co-corresponding authors, Grenoble, Lyon, France, 6Centre de Recherche en Cancerologie, Université Claude Bernard Lyon I, INSERM 1052, CNRS 5286, Lyon, France

11:10 am   E93    Mechanical modulation of glycolysis through phosphofructokinase and its activators in a KRAS-dependent manner. J. Park1, T. Isogai1, C.J. Burckhardt1, B. Gao1, R. Bachoo1, G. Danuser1; 1The Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX

11:20 am   E94    Cell signaling involved in acute glycolytic response to immune cell activation. Y. Kam1, P.M. Swain1, B.P. Dranka1; 1Cell Analysis, Agilent Technologies, Lexington, MA

11:30 am   E95    Posttranslational arginylation enzyme Ate1 controls mitochondrial functions and cellular Warburg effects. C. Jiang1, D.M. Patel1, A. Kumar1, B.T. Moorthy1, M. Birnbaum1, B. Alfonso2, J. Huang2, A. Barrientos3,4, T. Lampidis5,6, F. Fontanesi4, F. Zhang1,6; 1Molecular & Cellular Pharmacology, University of Miami, Miami, FL, 2Human Genetics, University of Miami, Miami, FL, 3Department of Neurology, University of Miami, Miami, FL, 4Biochemistry & Molecular Biology, University of Miami, Miami, FL, 5Cell Biology, University of Miami, Miami, FL, 6Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL

11:40 am   E96    Environmental availability of cystine drives usage of glutamine as a TCA cycle substrate and causes glutamine addiction. A. Muir1, L.V. Danai1, D.Y. Gui1, C.Y. Waingarten1, C.A. Lewis2, M.G. Vander Heiden1,3; 1Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 2Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 3Dana-Farber Cancer Institute, Boston, MA

11:50 am   E97    A cleavage product of Polycystin-1 is a mitochondrial matrix protein that regulates mitochondria morphology and function. C. Lin1, M. Kurashige1, Y. Liu2, T. Wang1, V. Choudhary1, R. Hobbs1, L. Liu1, P. Lee3, P. Outeda4, F. Zhou1, N.P. Restifo3, T.J. Watnick4, W. Prinz1, X. Hong2, L.F. Menezes1, G.G. Germino1; 1Kidney Disease Branch; National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health (NIH), Bethesda, MD, 2Laboratory of Molecular Genetics; National Heart, Lung and Blood Institute, National Institutes of Health (NIH), Bethesda, MD, 3Center for Cell-Based Therapy; National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, 4Department of Medicine; Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD

12:00 pm   E98    AMPK regulates peroxisomal cargo proteins import via PEX5 phosphorylation. J. Jing1, D. Tripathi1, R. Dere1, C. Walker1,2; 1CPEH, Baylor College of Medicine, Houston, TX, 2CTCR, Texas AM University , Houston, TX

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