ASCB Rainbow


Subgroup X

Subgroup X: Neuronal Cytoskeleton: A Complex Interplay of Cytoarchitecture and Dynamics

8:30-11:05 am, Room 121B
Organizers: Laura Anne Lowery, Boston College; Kassandra Ori-McKenney, University of California, Davis; and Le Ma, Thomas Jefferson University

The architecture and remodeling of the neuronal cytoskeleton powers the development and plasticity of a functional nervous system. This is accomplished through cytoskeletal-generated forces that drive morphological changes in neurons, including neuronal migration, axon outgrowth, dendritic arborization, and synaptogenesis. The highly polarized morphology of the neuron and the resulting specialized physiology are often achieved through the coordination of broadly used cytoskeletal pathways modulated by neuronal specific proteins and programs. Novel molecular, genetic, and imaging techniques allow for molecular interrogation and analysis of cytoskeletal architecture and dynamics in the neuron with higher spatial and temporal resolution. This session will highlight novel findings and mechanistic insights into this exciting area of neuronal cell biology, and how these programs may go awry in neurodevelopment and neurodegenerative disease.

Presentations:

8:30-8:35 am- Welcome by organizers
8:35-8:50 am- Specializations of the axonal cytoskeleton. Scott Brady, University of Illinois, Chicago
8:50-9:05 am- Regulation of microtubule polarity during axon arbor development in vivo. Mary Halloran, University of Wisconsin-Madison
9:05-9:20 am- Tau’s role in regulating axonal microtubules is not what you think. Peter Baas, Drexel University
9:20-9:35 am- Competition between microtubule associated proteins directs motor transport. Kassie Ori-Mckenney, University of California, Davis
9:35-9:50 am- Mechanism mediating MAP7 regulation of microtubules in axon branching. Stephen Tymanskyj (Ma lab), Thomas Jefferson University
9:50-10:05 am- Regulation of neuron polarization and axon extension by the mitotic kinesin Kif20b. Noelle Dwyer, University of Virginia
10:05-10:20 am- XMAP215 contributes to the spatiotemporal guidance of microtubules and their interaction with F-actin inside growth cones. Paula Slater (Lowery lab), Boston College
10:20-10:35 am- How specificity is encoded in microtubule networks, the role of the tubulin code. Antonina Roll-Mecak, NIH/NINDS
10:35-10:50 am- Branch-specific microtubule destabilization mediates synapse elimination in the neuromuscular junction. Monika Brill (Misgeld lab), Technische Universitat Munchen
10:50-11:05 am- Microtubule severing enzymes in neural regeneration. David Sharp, Albert Einstein College of Medicine

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