ASCB Rainbow


Subgroup T

Subgroup T: The Intersection of Lipids and Proteins in the Secretory Pathway

1:30 – 5:30 pm, Room 119A
Organizers: Guillaume Thibault, Nanyang Technological University; and Prasanna Satpute-Krishnan, Uniformed Services University of the Health Sciences

Recent discoveries highlight the role of lipids and proteins as key drivers of critical biological functions in the secretory pathway and tightly associated compartments, such as lipid droplets and autophagosomes. These functions include lipid and protein homeostasis, cell signaling, and protein quality control and secretion. This subgroup will provide a platform for researchers coming from traditionally distinct fields of lipid and protein biology to discuss common interests in lipid-protein interactions. Specific topics include: sphingolipid biosynthesis, lipid droplets formation and lipid trafficking, lipid homeostasis and the unfolded protein response (UPR), ER-associated protein degradation (ERAD), GPI-anchor processing, protein quality control, and lipid-protein interactions in the formation of membrane microdomains.

Presentations:

1:30-1:35 pm- Opening remarks. Prasanna Satpute-Krishnan, Uniformed Services University of the Health Sciences; Guillaume Thibault, Nanyang Technological University
1:35-2:00 pm- Lipid droplets: organelle crosstalk and cellular functions. James Olzmann, University of California, Berkeley
2:00-2:25 pm- Role of transmembrane domain 1 of LCB1 in ORM regulation of serine palmitoyltransferase. Teresa Dunn, Uniformed Services University of the Health Sciences
2:25-2:50 pm- Lipid droplet budding from specialized ER domains. William Prinz, National Institutes of Health
2:50-3:15 pm- Mechanisms of membrane protein quality control. Pedro Carvalho, University of Oxford
3:15-3:40 pm- Dissecting the role of the UPR during lipid perturbation. Guillaume Thibault, Nanyang Technological University
3:40-4:05 pm- Recognition of transmembrane domains during protein quality control. Malaiyalam Mariappan, Yale School of Medicine
4:05-4:30 pm- Structural changes of GPI-anchor in the secretory pathway. Taroh Kinoshita, Osaka University,
4:30-4:55 pm- Protein quality control in the secretory pathway. Prasanna Satpute-Krishnan, Uniformed Services University of the Health Sciences
4:55-5:20 pm- Regulation of protein recruitment to plasma membrane platforms by lipid phase separation: implications for viral assembly and microvesicle biogenesis. Prabuddha Sengupta, Howard Hughes Medical Institute, Janelia Research Campus
5:20-5:30 pm- Closing remarks

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