ASCB Rainbow


Subgroup E

Subgroup E: Microtubule Motors: Emergent Phenomena and New Paradigms

8:30 am – 12:30 pm, Room 118C
Organizers: William Hancock, Penn State University; Weihong Qiu, Oregon State University

Kinesin and dynein are microtubule-based motor proteins that transform the chemical energy of ATP hydrolysis into mechanical work for a variety of essential processes including transport of intracellular cargo and mitotic spindle assembly. Recent advances have revealed a number of paradigm-shifting discoveries and emergent phenomena, which include but are not limited to i) the discovery of bidirectional kinesins; ii) the discovery of processive kinesin-14 motors; iii) the discovery of non-canonical kinesin activities; and iv) the regulation of intraflagellar transport dynein. This subgroup meeting will provide a cohesive update of these new and exciting developments. Presentations will be followed by an interactive discussion involving all participants and audience members focused on challenges and opportunities in this area.

Presentations:

8:30-8:40 am- Introduction. William Hancock, Penn State University
8:40-9:05 am- Stapling and straightening: the kinesin-5 microtubule polymerase mechanism. William Hancock, Penn State University
9:05-9:30 am- New insights into the bidirectional motility of kinesin-5 motors. Leah Gheber, Ben-Gurion University of the Negev
9:30-9:55 am- Ensembles of bidirectional kinesin Cin8 produce additive forces in both directions of movement. Thomas Surrey, The Francis Crick Institute, UK
9:55-10:20 am- Switching on and off the motor activity of intraflagellar transport dynein. Anthony Roberts, University of London
10:20-10:40 am- Break
10:40-11:05 am- Engineering novel processive minus-end-directed kinesin-14 motors. Weihong Qiu, Oregon State University
11:05-11:30 am- Diffusive anchorage of molecular motors allows for adaptive force generation. Stefan Diez, Technische Universität Dresden
11:30-11:55 am- Role of minus-end-directed kinesin-14 motors in mitotic spindle organization. Melissa Gardner, University of Minnesota
11:55 am -12:20 pm- Formation of parallel microtubule networks at microtubule-organizing centers. Maxim Molodtsov, Research Institute of Molecular Pathology
12:20-12:30 pm- Closing & General Discussion

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