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Minisymposium 9

Minisymposium 9: Ensuring Fidelity of Chromosome Segregation

4:15-6:50 pm
Room 108A
Co-Chairs: Elcin Unal, University of California, Berkeley; and Jorge Z. Torres, University of California, Los Angeles

4:15 pm       Introduction

4:20 pm   M89    Role of chromatin and repetitive DNA in centromere formation and propagation. J. Palladino1, A. Chavan1, A. Sposato1, B. Mellone1,2; 1Molecular and Cell Biology, University of Connecticut, Storrs, CT, 2Institute for Systems Genomics, University of Connecticut, Storrs, CT

4:35 pm   M90    Condensin complexes promote chromosome movement during mitosis. K.R. Salmon1,2, D.A. Compton1,2; 1Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 2Norris Cotton Cancer Center, Lebanon, NH

4:50 pm   M91    Chromokinesin Kif4 is required for faithful chromosome segregation in mammalian oocytes. C.M. Heath1, S.M. Wignall1; 1Molecular Biosciences, Northwestern University, Evanston, IL

5:05 pm   M92    Human centromeres produce non-coding alpha satellite RNAs that are chromosome-specific and required for centromere protein loading. S.M. McNulty1, L.L. Sullivan1, B.A. Sullivan1,2; 1Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, 2Division of Human Genetics, Duke University, Durham, NC

5:20 pm   M93    Kinetochore inactivation by expression of a repressive mRNA. E. Ünal1, J. Chen1, A. Tresenrider1, M. Chia2, F. van Werven2; 1Molecular and Cell Biology, UC Berkeley, Berkeley, CA, 2Francis Crick Institute, London, United Kingdom

5:35 pm   M94    Most kinetochore fibers in human cells form via mechanisms intrinsic to the kinetochores and not by capture of astral microtubules. V. Sikirzhytski1, F. Renda1, I. Tikhonenko1, B.F. McEwen1, A. Khodjakov1; 1Transnational Medicine, Wadsworth Center, Albany, NY

5:50 pm   M95    Identification and characterization of novel spindle assembly checkpoint components. J.Z. Torres1, Y.A. Garcia1, I. Ramirez1, A. Gholkar1, Q. Yang1, S. Senese1, J. Ong1, T. Falegan1, K.S. Morillo1, N. Filbert1, Q. Dam1; 1Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA

6:05 pm   M96    The Mad1/Mad2 spindle checkpoint complex is repurposed in development to promote cell cycle progression. P. Lara Gonzalez1, J. Mendoza1, M. Moyle2, K. Oegema1,3, A.B. Desai1,3; 1Ludwig Cancer Research San Diego, La Jolla, CA, 2 Yale School of Medicine , New Haven, CT, 3Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA

6:20 pm   M97    Sensing of the Magnitude of Centromeric Tension at Metaphase Elicits a Graded Cellular Response. S. Mukherjee1, D. Tank1, Q. Yang1, M.K. Gardner1; 1Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN

6:35 pm   M98    Microtubule sliding in the bridging fiber pushes kinetochore fibers apart to segregate chromosomes in human cells. P. Risteski1, K. Vukušić1, R. Buđa1, A. Bosilj2, A. Milas1, N. Pavin2, I.M. Tolić1; 1Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia, 2Department of Physics, Faculty of Science, University of Zagreb, Zagreb, Croatia

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