Minisymposium 5: Organelles in Metabolism and Stress Responses
Co-Chairs: Mike Henne, UT Southwestern Medical Center; and Shawn M. Ferguson, Yale University
4:15 pm Introduction
4:20 pm M41 Lipid Droplet Biogenesis Is Spatially Coordinated at Yeast ER-Lysosome Contact Sites in Response to Nutritional Stress. H. Hariri1, S. Rogers1, R. Ugrankar1, Y. Liu1, R. Feathers1, M. Henne1; 1Cell Biology, UT Southwestern Medical Center, Dallas, TX
4:35 pm M42 Measurement of caveolin-1 densities in the cell membrane for quantification of caveolar deformation after exposure to hypotonic membrane tension. M. Tachikawa1, N. Morone2, S. Suetsugu3; 1Theoretical Biology Laboratory, RIKEN, Wako, Japan, 2MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom, 3Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Japan
* 4:50 pm M43 Membrane dynamics during cellular wound repair. N.R. Davenport1,2, K.J. Sonnemann3, K.W. Eliceiri3,4, W.M. Bement1,3,5; 1Program in Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, WI, 2Thermo Fisher Scientific, Eugene, OR, 3Laboratory of Cell and Molecular Biology, University of Wisconsin-Madison, Madison, WI, 4Laboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, Madison, WI, 5Department of Zoology, University of Wisconsin-Madison, Madison, WI
5:05 pm M44 Deciphering the function of CLYBL, a missing human gene and a mitochondrial orphan metabolic enzyme. H. Shen1, V. Mootha1; 1Department of Molecular Biology, Massachusetts General Hospital/Howard Hughes Medical Institute, Boston, MA
5:20 pm M45 The Unfolded Protein Response Maintains Lipid Homeostasis by Selective Autophagy during Lipid Perturbation-Induced ER Stress. J. Koh1, L. Wang2, C. Beaudoin-Chabot1, G. Thibault1,2; 1School of Biological Sciences, Nanyang Technological University, Singapore, Singapore, 2Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
5:35 pm M46 TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes. R.A. Willett1, J.A. Martina1, R. Puertollano1, G. Hammond1, J.P. Zewe1; 1Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA
5:50 pm M47 Mitochondrial subpopulations exhibit differential dynamic responses to support increased energy demand during exocytosis. N. Porat-Shliom1, L.N. Malec1, O. Harding1, R. Weigert1; 1Laboratory of Cellular and Molecular Biology, National Institute of Health, NCI, Bethesda, MD
6:05 pm M48 Regulated recruitment of C9orf72 to lysosomes supports diverse signaling and degradative functions. J. Amick1, A. Tharkeshwar1, C. Amaya1, S.M. Ferguson1; 1Cell Biology, Yale University, New Haven, CT
6:20 pm M49 3D ultrastructural analysis of the progressive restructuring of the endoplasmic reticulum by a coronavirus provides insight into its subversion of the ERAD tuning pathway. E.M. Mihelc1, S.A. Tinney1, S.C. Baker2, J.K. Lanman1; 1Biological Sciences, Purdue University, West Lafayette, IN, 2Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine, Maywood, IL
6:35 pm M50 The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading. B.M. Gardner1, D.T. Castanzo1, S. Chowdhury2, G. Stjepanovic1,3, M.S. Stefely1, J.H. Hurley1,3,4, G.C. Lander2, A. Martin1,4,5; 1Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 2Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 3Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 4California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, 5University of California, Berkeley, Howard Hughes Medical Institute, Berkeley, CA
*Nick Davenport is the recipient of the Molecular Biology of the Cell Paper of the Year Award.
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