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Minisymposium 16

Minisymposium 16: Mechanical Coupling from Nucleus to Extracellular Matrix

4:40-7:15 pm
Room 113B
Co-Chairs: Gijsberta Koenderink, NWO Institute AMOLF; and Kandice Tanner, National Cancer Institute, NIH

4:40 pm       Introduction

5:00 pm   M160    YAP-independent mechanotransduction drives breast cancer invasion. J.Y. Lee1, J. Chang2, S. Nam1, H. Lee1, A. Dominguez3,4,5, S. Varma6, L.S. Qi3,4,5, R. West6, O. Chaudhuri1; 1Mechanical Engineering, Stanford University, Stanford, CA, 2Genetics, Stanford University, Stanford, CA, 3Bioengineering, Stanford University, Stanford, CA, 4Chemical and Systems Biology, Stanford University, Stanford, CA, 5ChEM-H, Stanford University, Stanford, CA, 6Pathology, Stanford University, Stanford, CA

5:15 pm   M161    Force-activated vinculin dynamics regulate sub-cellular processes critical in directed cell migration. K.E. Rothenberg1, D.W. Scott2, B.D. Hoffman1; 1Biomedical Engineering, Duke University, Durham, NC, 2Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, NC

5:30 pm   M162    Human brain organoids on a chip to model normal development and disease. O. Reiner1, E. Karzbrun1, S. Cohen1; 1Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

5:45 pm   M163    Cellular force propagation through monolayers investigated by tracking sub-nuclear sensors. T.J. Armiger1, M. Lampi2, C. Reinhart-King3, K.N. Dahl1; 1Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, 2Biomedical Engineering, Cornell University, Ithaca, NY, 3Biomedical Engineering, Vanderbilt University, Nashville, TN

6:00 pm   M164    Force triggers YAP nuclear entry by mechanically regulating transport across nuclear pores. A. Elosegui-Artola1, I. Andreu2,3, A. Beedle4, A. Lezamiz4, M. Uroz1, A. Kosmalska1,5, R. Oria1,5, J.Z. Kechagia1, P. Rico-Lastres4,6, A. Le Roux1, C.M. Shanahan4, X. Trepat1,5,7, D. Navajas1,5, S. Garcia-Manyes4,6, P. Roca-Cusachs1,5; 1Institute for Bioengineering of Catalonia, Barcelona , Spain, 2Mondragon University, Arrasate, Spain, 3CEIT and TECNUN (University of Navarra), San Sebastian, Spain, 4Randall Division of Cell and Molecular Biophysics, King’s College London, London, United Kingdom, 5University of Barcelona, Barcelona, Spain, 6King’s College London, King’s College London, London, United Kingdom, 7Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona , Spain

6:15 pm   M165    Forces and dynamics in three-dimensional epithelia of controlled size and shape. E. Latorre1,2, L. Casares1, S. Kale2, M. Gomez-Gonzalez1, M. Uroz1, L. Valon1, M. Arroyo1,2, X. Trepat1,3,4,5; 1Institute for Bioengineering of Catalonia, Barcelona, Spain, 2Universitat Politècnica de Catalunya-BarcelonaTech, Barcelona, Spain, 3University of Barcelona, Barcelona, Spain, 4Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain, 5Centro de Investigación Biomédica en Red en Bioingeniería, Biomat. y Nanomed., Madrid, Spain

6:30 pm   M166    Tissue explant imaging reveals spatially coordinated migration patterns in the tumor core. R. Staneva1, F. El Marjou1, A.G. Clark1, D. Matic Vignjevic1; 1Institut Curie, Paris, France

6:45 pm   M167    Conservation of organo-tropic metastasis of human tumor cells in a zebrafish xenograft model. K. Tanner1, C.D. Paul1; 1LCB, NCI/NIH, Bethesda, MD

7:00 pm   M168    Cell-free reconstitution of cytoskeletal dynamics, mechanics and motility. G.H. Koenderink1; 1Systems Biophysics, AMOLF, Amsterdam, Netherlands

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