ASCB Rainbow


Microsymposium 12

Microsymposium 12: Mechanoregulation and Translational Studies of the Cytoskeleton

1:50 pm-3:00 pm
Microsymposia Room, 2 Hall C
Moderators: Pinar Gurel, The Rockefeller University; and Ashley Lakoduk, University of Texas Southwestern Medical Center, Dallas

1:50 pm   E78    Graded activation of ROCK and MLCK tunes regional stress fiber formation and mechanics via preferential myosin light chain phosphorylation. E. Kassianidou1,2, J.H. Hughes1,2, S. Kumar1,3; 1Bioengineering, University of California, Berkeley, Berkeley, CA, 2UC Berkeley – UCSF Graduate Program in Bioengineering, Berkeley, CA, 3Chemical and Biomolecular Engineering, University of Berkeley, Berkeley, CA

2:00 pm   E79    Profiling mechanical stress-dependent cytoskeleton organization at varying curvatures using self-induced rolling membrane (SIRM). J. Kim1, L. Vannozzi2, Y. Chen1,3; 1Mechanical Engineering , Johns Hopkins University, Baltimore, MD, 2The BioRobotics Institute, Sant’Anna School of Advanced Studies, Pisa, Italy, 3Center for Cell Dynamics, Johns Hopkins University, Baltimore, MD

2:10 pm   E80    Morphological changes of epithelia cells induced by viscous conditions. J. Flournoy1, G. Sun1, D. Maity2, Y. Chen1; 1Mechanical Engineering, Johns Hopkins University, Baltimore, MD, 2Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore , MD

2:20 pm   E81    Myofibroblast differentiation of fetal fibroblasts is inhibited in response to ECM rigidity and TGF-b1. R.J. Jerrell1, M.J. Leih1, A. Parekh1,2,3,4; 1Otolaryngology, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, 3Biomedical Engineering, Vanderbilt University, Nashville, TN, 4Cancer Biology, Vanderbilt University, Nashville, TN

2:30 pm   E82    Molecular force loading explains cell sensing of extracellular ligand density and distribution. R. Oria1,2, T. Wiegand3,4, J. Escribano5, A. Elosegui-Artola1, J. Uriarte2, C. Moreno-Pulido1, I. Platzman3, P. Delcanale1, L. Albertazzi1, D. Navajas1,2, X. Trepat1,2,6, J.M. García Aznar5,  .A. Cavalcanti-Adam3,4, P. Roca-Cusachs1,2; 1Institute for Bioengineering of Catalonia, Barcelona, Spain, 2University of Barcelona, Barcelona, Spain, 3Max-Planck-Institute for Medical Research, Heidelberg, Germany, 4University of Heidelberg, Heidelberg, Germany, 5Multiscale in Mechanical and Biological Engineering (M2BE),  University of Zaragoza, Zaragoza, Spain, 6Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain

2:40 pm   E83    Laser-induced retraction of single actomyosin stress fibers reveals subtype-specific viscoelastic properties and contributions to tension generation. S. Lee1, S. Kumar1,2,3; 1Graduate Program in Bioengineering, UC Berkeley-UCSF, Berkeley, CA, 2Bioengineering, University of California, Berkeley, Berkeley, CA, 3Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA

2:50 pm   E84    Actin-generated forces during mammalian endocytosis. M. Akamatsu1, D.G. Drubin1; 1Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA

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